Home Β» CBD and Drug Interactions: An Easy Guide

**IMPORTANT: CBD AND DRUG INTERACTIONS ARE NOT A JOKE. IF YOU WANT TO START TAKING CBD AND ARE ALREADY TAKING OTHER MEDICATIONS, PLEASE CHECK WITH YOUR DOCTOR FIRST!**

While CBD is safe to use, it can potentially mess with other medications you may be taking.

This quick guide should be all you need to safely use CBD even if you have other medications you need to take.

Can CBD interact with other drugs?

Yes. The way that CBD is metabolized by your body can interfere with how your body normally metabolizes other drugs you take. If those other drugs arn’t metabolized properly, they can hang around and stay in your system longer than you want. This can cause negative side effects and complications.

One kind of drug you should pay special attention to is a blood thinner like warfarin. Taking CBD with warfarin can make the warfarin stay in your system for too long without being broken down.

CBD drug interactions arn’t always bad. They can actually be a good thing. CBD can make other drugs more effective, so much so that you can reduce the dosage of those other drugs and thus have less negative side effects to deal with.

Read about how Alex reduced his epilepsy medication (under doctor supervision) by using CBD.

 

The Grapefruit Test is all you need

Thank you to Martin Lee of Project CBD for inspiring the Grapefruit Test. If you haven’t been to Project CBD yet, make sure to check it out. They are running a great site with lots of useful information about cannabis medicine.

As Lee explained in his classΒ CBD 101,Β CBD interacts with other medications in your body in the same way as grapefruit, only even stronger.

grapefruit 154469 640

Have you ever been told not to take your medication with grapefruit? This is because compounds in grapefruits can interfere with the metabolism of many medications.

CBD does the same thing. But as I said above, the effect is even stronger with CBD.

Do the grapefruit test with your doctor or pharmacist. Ask them: “Should I avoid eating grapefruits or drinking grapefruit juice with this medication?”

They will know exactly what you are talking about. If they say yes, you should avoid grapefruits with your medication, you now know you need to be careful about mixing CBD with those same meds as well. Talk to your doctor about CBD and tell them about it if they say you should avoid grapefruits with your medication.

Useful links for CBD and drug interactions

Cannabis Drug Interactions

RxList on Grapefruit and Drug Interactions

Drug Interactions with Grapefruit Juice

Wikipedia: Grapefruit Drug Interactions

Washington D.C.’s Department of Health Medical Cannabis Slide Deck (look for the sections on CBD drug interactions)

Alternatively, you can skip the Grapefruit Test and just directly tell your doctor you want to use CBD.

We always recommend you do this anyway, even if your doctor doesn’t work with cannabis. Medical schools don’t educate physicians about the endocannainoid system, the most widespread receptor system in the human body. But that doesn’t mean we shouldn’t educate them about it!

If your doctor is aware of your CBD usage, he may decide to monitor your blood work more closely or tell you to avoid taking CBD at the exact same time as your other medications.

Play it safe and keep CBD safe. If you take other drugs, make sure they won’t interact negatively with CBD before you start taking CBD.

~ Vadim the CBD Professor

24 comments

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    • Hey Joe. Thanks for your question. I am not a doctor or medical professional so I would not be able to answer your question. I recommend you speak with your prescribing doctor before taking CBD oil. Some good places to research drug interactions with CBD would be this post as well as this post from Project CBD.

    • Hey Julie. Thanks for your question. I think CBD oil is definitely worth a try if you have epilepsy. But I always recommend checking with your doctor first and working alongside their supervision, especially if you are taking other medication already for epilepsy. Please let me know if you have other questions and I will do my best to help πŸ™‚

  • Hi,

    Do you know of information about interactions with blood thinners specifically, metoprolol or where I can find the information?

    Thank you

    • Hey Pauline. Thanks for your question. CBD can alter the blood levels of another drug being taken. I always recommend speaking to your doctor or pharmacist first before you start using CBD, just to be on the safe side. Most people do not have serious problems with drug interactions but again, always better to be safe.

    • Hey Kristin. Thanks for your question. I wish I could answer that but it’s completely outside my realm of expertise. My vet of choice for these types of questions is Gary Richter. He is a well experienced veterinarian who has a lot of experience working with CBD. Make sure to Google him and I bet he can answer you question. I hope that helps and please let me know if you have any other questions πŸ™‚

    • Hey Marty. Thanks for your question. Unfortunately I do not know the answer as I am not a veterinarian. My veterinarian of choice who has a lot of experience working with cannabis is Dr. Gary Richter. You may also be able to ask your vet this question and get an answer. I hope that helps.

  • Have you heard of unwanted side effects for taking cbd oil with biologics and methotrexate? I know it may change the way my body metabolizes the meds I take and I have to have frequent blood-work for my liver & kidney function. The biologics and methotrexate have become less effective, either due to progression of my disorder or because my body has become resistant over the past 10 years. I’m in constant, severe pain, looking for relief where ever it may be found.

    • Hey Jeris. Thanks for your inquiry and I am sorry to hear about your condition. Unfortunately, I have never heard of unwanted side effects from this specifically. I recommend to speak with a doctor as soon as possible.

    • Hey Mrs. Storkey. Thanks for your inquiry. Unfortunately I cannot answer that as I am not a doctor. Please check with your doctor or pharmacist. What I can tell you is that most people do not have problems with drug interactions and CBD. Still I urge you to be cautious and check with a medical professional. Let me know please if there is anything else I can help you with πŸ™‚

    • Hey John. Thanks for your question. Unfortunately I cannot answer this as I am not a doctor. Please check with your doctor or pharmacist. What I can tell you from my anecdotal experience is that most people do not have problems with drug interactions and CBD. Still I urge you to be cautious and check with a medical professional. Let me know please if there is anything else I can help you with πŸ™‚

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